tyc澳门太阳集团城网址 - 太阳集团城网址娱网

党建群团工作委员会

杨建国

邮箱:yangjg@pku.edu.cn

研究领域:合成生物学,生物固氮,微生物学

简介

个人简介

研究员、博士生导师、国自然优青项目获得者。

 

教育经历

2010年毕业于厦门大学生命科学学院,获得学士学位;2015年毕业于北京大学生命科学学院,获得博士学位;2015年7月至2019年9月在北京大学生命科学学院继续开展博士后研究;2019年9月加入tyc澳门太阳集团城网址。

 

研究方向

本课题组长期致力于解决农业生产中氮肥的问题,主要以合成生物学为研究手段,开展对复杂生物系统和复杂通路的工程化重构以及异源表达;同时通过理性设计提升农作物氮肥利用率。近期研究主要集中在利用合成生物学手段对固氮酶系统进行工程化改造,以期实现固氮酶系统的异源底盘转移:包括1)将固氮酶系统导入作物根际定植优势菌实现高效联合固氮;2)将固氮酶系统从原核生物转移到真核生物乃至主要农作物,从而实现农作物的自主固氮,减少或消除化学氮肥的使用,实现农业的绿色和可持续发展。目前已经在PNAS(4篇,其中两篇为封面推荐)、Cell、Science Advances、Open Biology等杂志发表多篇研究论文。

 

发表论文(#,Co-first author; *, Corresponding author)

1.Feng Jiang*#, Jiawei Shen#, Jiaxuan Cheng#, Xia Wang, Jianguo Yang, Ningning Li, Ning Gao, Qi Jin*. (2022) N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system. Science Advances. 8: eabm2343.

2.Nan Xiang, Chenyue Guo, Jiwei Liu, Hao Xu, Ray Dixon*, Jianguo Yang*, Yi-Ping Wang*. (2020) Using synthetic biology to overcome barriers to stable expression of nitrogenase in eukaryotic organelles. PNAS. 117(28): 16537-16545.

3. Feng Jiang, Ningning Li, Xia Wang, Jiaxuan Cheng, Yaoguang Huang, Yun Yang, Jianguo Yang , Bin Cai, Yi-Ping Wang, Qi Jin, Ning Gao. (2019) Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System. Cell . 177: 1–14.

4. Jianguo Yang#, Xiaqing Xie#, Nan Xiang, Zhe-Xian Tian, Ray Dixon*, and Yi-Ping Wang*. (2018) Polyprotein strategy for stoichiometric assembly of nitrogen fixation components for synthetic biology. PNAS . 115 (36): E8509-E8517. (当期封面推荐文章,同期刊登评论文章点评) [highlighted with commentary by Stefan Burén  et al . (2018) Extreme bioengineering to meet the nitrogen challenge. PNAS . 115 (36): 8849-8851] 

5. Jianguo Yang#, Xiaqing Xie#, Mingxuan Yang, Ray Dixon*, and Yi-Ping Wang*. (2017) Modular electron-transport chains from eukaryotic organelles function to support nitrogenase activity. PNAS . 114 (12) E2460-E2465. (当期封面推荐文章,同期刊登评论文章点评) [highlighted with commentary by Vicente and Dean. (2017) Keeping the nitrogen-fixation dream alive. PNAS . 114 (12): 3009-3011; Selected by the Royal Society of Biology (UK) as one of the Big Biology Breakthroughs of 2017]

6. Jianguo Yang, Xiaqing Xie, Xia Wang, Ray Dixon*, and Yi-Ping Wang*. (2014) Reconstruction and minimal gene requirements for the alternative iron-only nitrogenase in Escherichia coli . PNAS . 111 (35) E3718-E3725.

7. Jiwei Liu#, Jianguo Yang#, Jin Wen#, Yun Yang, Xiaolu Wei, Xiaodong Zhang, Yi-Ping Wang*. (2014) Mutational analysis of dimeric linkers in peri- and cytoplasmic domains of histidine kinase DctB reveals their functional roles in signal transduction.  Open Biology . 4: 140023.

8. Xia Wang, Jianguo Yang, Li Chen, Jilong Wang, Qi Cheng, Ray Dixon, Yi-Ping Wang. (2013) Using Synthetic Biology to Distinguish and Overcome Regulatory and Functional Barriers Related to Nitrogen Fixation. PLoS ONE . 8(7): e68677.